To get really mad about something to the point of yelling or fighting. To go out of one's mind because of the gravity of the seriousness of the situation. To lose it or flip out. Origin: The Washington DC area (DC, Maryland and Virginia). Reference to Captain Kirk from Star Trek and the way he used to sign off of the com speaker "Kirk out" when he was upset.

The best answer to literally anything

to go off, to get really upset......to exhibit rage or anger.

Being overly mad at soemthing.
Synonyms: freak out, flip out, go ape shiznit.

To be so extremely pissed off at a situation or person that you can only talk in short chopped sentences like Captain Kirk from Star Trek.

The opposite of a greeting.

Most often used when talking on a cell phone or 2-way radio.

References Capt. Kirk of Star Trek fame, when he would conclude all dialogs from the planet to the Enterprise with this phrase.