I.S. 

Information Systems

High School computer geeks usually go on to lucrative careers in I.S. departments.

I.S. by Tom Cumbow January 23, 2004

i.s. 

independent study

i am part of i.s.

i.s. by rick June 8, 2003

I.S. 

Pronounced ‘Aiy’ ‘Ess’
Short for Infatuated Spaz. A person who is so besotted by someone that they don’t mind being verbally or physically abused by them.

“Hey man you really shit on your girl don’t you?”
“Don’t worry about her she’s my I.S.

I.S. by Prime Dean July 29, 2018

I.S. 

The term for a man's rather large thang "Italian sausage"

"Yoo girl u want to taste some of this italian sausage?"

I.S. by Nigga Dust May 24, 2005

i.s. 

inverse smile

i.s.

i.s. by t. sheather November 3, 2002

I.S. 

Short for Itis Spot. A designated chill spot for a group of friends to chill and get over the itis (short for niggeritis)
Pronounced "is" not i.s.

"Yo dude, the itis is hittin' me quicktime, let's hit up I.S."

Friend 1: "Yo, ima go home and get some sleep before soccer dude."
Friend 2: "Nah, let's just hit up I.S. for a quick minute."

I.S. by Casey Rexdale January 12, 2009

i.s. 

I stupid...me kno nothing

I.S. didn't ya kno that?

i.s. by Tanya December 31, 2003