This basically means Get the fuck out/get the freak out.
Guy 1:Mane you're acting weird
Guy 2: GTFO
by Boba Fett (real1!1!1!) May 19, 2022
Gtfo meaning get the fuck on as in shut up or it can mean get the fuck out as in get tf out.
by Kayla a g July 23, 2022
Short for Girls That Fake Orgasms
That girl doesn't like the sex with his boyfriend, but she still wants to please him. She's a GTFO
by laklek November 24, 2021
I have a nikka gtfo with that shii

GTFO
by Sy su September 20, 2020