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The brand name of a type of household drain cleaner.
EXAMPLE:

' But now Midland City looked unfamiliar and frightening to Dwayne. "Where am I?" he said.

' He even forgot that his wife Celia had committed suicide, for instance, by eating Drano --- a mixture of sodium hydroxide and aluminum flakes, which was meant to clear drains. Celia became a small volcano, since she was composed of the same sorts of substances which commonly clogged drains. '

--- 1973. KURT VONNEGUT. "Breakfast of Champions, or, Goodbye Blue Monday." Chapter 6 (Page 65).
Drano by Dinkum February 15, 2014
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Mike was known for making unlimited shots at the 3 point line so we called him Drano.
Drano by Blaqjade13 December 24, 2019
A semi-derisive slang term for the Draenei, a playable character race on the Alliance side from Blizzard's MMORPG World of Warcraft.
We wiped again! Who let that Drano idiot tank?
Drano by CoilSlade February 5, 2010

Drano Bomb 

Something to make when bored. You will get addicted after you make the first one, and try to find ways to make it bigger and better.
A: Hey, what are you doing now?
B: Nothing.
A: Do you want to go make a drano bomb near sunny slopes.
B: Isn't that close to the police station.
A: Who cares?
B: Sure!
Drano Bomb by Stizzz December 26, 2008

Drano Margarita Abortion 

The cheapest, classiest way to induce early termination of an unwanted pregnancy. Make a margarita, and add 1/2 cap of drano for every two weeks she has been pregnant.
Kevin B: Damn, Sheila says she is pregnant, and she is too religious to get that little bastard sucked out.

Bart: Looks like that bitch is beggin for the old Drano Margarita Abortion.

Kevin B: Does it work?

Bart: 60% of the time, it works every time. Its a family tradition going back to my fillandering grandfather.

Kevin B: You are full of magical ideas my friend.

drano bomb 

Put commercal toilet cleaner with aluminum in a bottle. will blow up im 3 secs after cap is closed. ***warning will blind you!!!***
drano bomb by Anonymous August 16, 2003

drano brain 

Meth users. Heavy users whose brains are so fried they should no longer be considered members of the human race.
Tom and Sally now belong in the drano brain class of non humans.
drano brain by CoolLiving November 24, 2017