Genetic condition caused by a triple chromosome also known as chromosome 21. People with this condition are blessed with the gift of eternal innocence. They are usually harmless and friendly and incapable of violence. We like to think they need help but maybe it's really us who do.
"George Bush is a perfectly sain individual, no history of downsyndrom there, he can wage war all he wants"
by Flo January 29, 2004
 Get the downsyndromemug.
Get the downsyndromemug. An extremely intelligent person who doesn't deserve hatred. Please keep the negative comments about Down syndrome people to yourself. Thank you
by alay.s May 5, 2016
 Get the Downsyndromemug.
Get the Downsyndromemug. A person who is always down and it a bad mood, and puts others in bad moods as well. Usually is in a bad mood from being ugly or gettin made fun of.
by Todd Fisher April 21, 2008
 Get the Debbie Downsyndromemug.
Get the Debbie Downsyndromemug. When two adults with down syndrome have a kid who also has down syndrome. Jokingly the kid would have twice as many extra chromosomes.
by 👉😉👈 This guy February 21, 2019
 Get the Double Downsyndromemug.
Get the Double Downsyndromemug.