21
Dark brown or black cannabis remaining in a vaporizer bowl after vaporizing. The duff, which still contains some THC, is recycled rather than discarded by stingier enthusiasts.
Whoa, don't toss that duff, man! I'm saving that to make hash.
by John Woods August 25, 2008
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22
Literally stands for Designated Ugly Fat Friend. This is the bitch who comes out of no where to cockblock you when you are about to get a chick home with you. She is often recognizable by her fat ass, bad hair and sour disposition. Her main goal of the night is to fend off any advances on her friend so she will have company at the diner when she is stuffing her fat face with an omelet and a side of disco fries while she bitches about anyone and everyone. The D.U.F.F can be defeated with a high level wingman, but you will be expected to return the favor; a job not for the faint of heart. A naked D.U.F.F often smells like a box of crayons.
"Dude, I was about to bag this chick, but then her army of D.U.F.F's came out of no where and pulled her away. She must be a Volleyball player!"

"Did you Fuck the chick at the party?"
"No Fuckhead, I got Duffed!"
by LexDimonds July 31, 2009
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23
Timmy: Chelsey and sarah are so hot. why does she hang around with heather. she is so fat.
Bryan: Heather is their DUFF to make them look better
by shortman94 March 29, 2010
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24
Scottish slang for a vagina

Also means something is rubbish, crap or broken
I'll kick you in the duff

That's totally duff
by Freakosaurus November 17, 2006
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25
(Da Ugly Fucking Friend) A term to describe the less attractive females another female will have in company to make her seem more attractive or just a less attractive friend to more attractive female. (Originating in Bear, Delaware)
Jon: "Hey! did you see that girl that just walked by?"

Brandon: "Which one?"

Jon: "The one in the middle bro!"

Brandon: "Oh yeah, but she's only a 6 on a scale of 1-10 without those DUFFs."

Jon: "Yeah her other friends were pretty ugly."
by Boogey Man Brown October 05, 2011
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26
Dumb Ugly Fat Friend: Usually accompied by the attractive girl that you actually want to talk to.
That girl is so hot, but she has that Duff standing next to her.
by Cody August 23, 2004
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27
the act of locking the door behind you when you arrive to your place to lockout someone who may intrude or barge in unexpectedly.
"Hey did you duff the lock? Yeah man, don't worry I duffed it."
by Pants007 January 20, 2009
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