Jack Blade quote from Tropic Thunder. His character was experiencing withdrawl from cocaine and he was tied to a tree. Crazy shit ensued.

Basically, It means your mother sleeps with everyone and has deseases between her legs, and most likely, you are unwanted crotchspawn.
"Your mother is a cankerous whore!"
"Damn."
"Hey, remember that time I called your mother a cankerous whore? I didn't mean it man, she's a nice lady." - Tropic Thunder
by Allie-Rose March 12, 2009
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In short terms someone that has a canker sore on their penis dude
Dude I think I have a bad case of canker dick it hurts bro
by Rootwitch June 9, 2020
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A female who either has a nasty-ass pussy from being a whore or a bitch who has canker-like sores on her pussy, also from being a whore.
I love my sister, but she really is a fuckin canker-cunt!
by LilosLingo August 2, 2015
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A nasty female/male your son/daughter is currently dating that has a bunch of unkept kids, will not work, lives to beg for help on any social media and rides the welfare system instead of doing anything to help themselves. This is just nasty, vile and no class or tact at all.
Jordans new g/f amber is an ass-canker.
by Lilmizdiz September 26, 2021
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