To tell someone not to touch you, or to get off of you.
Get away from me. Don't touch me.

Be up off me,Fool! You be up off me, or I'll kick your ass!
by eileen March 9, 2005
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If a girl aint on shit tell them this cuz it means fuck off
Spin up Off me since u aint talkin about shit
by Big boi 09 September 3, 2009
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