21-Abrego Share definition Flag 21-Abrego is the San Angelo slang term to describe someone who gets 21-skunked and rage quits before half-time. "Man, fuck this. I quit." "Bro, it's not even halftime. That's a 21-Abrego." 21-Abrego by Mshark October 27, 2014 0 0 Get merch Get the 21-Abrego mug. Buy Now — $32.95 See more merch