1-2 Mayweather Share definition Flag The act of fighting/punching someone. Often followed with the 3-4 McGregor. Popularized by the NELK boys. Buddy was talkin' shit, had to give him the 1-2 Mayweather 1-2 Mayweather by Miguel Viper April 23, 2018 0 0 Get merch Get the 1-2 Mayweather mug. Buy Now — $32.95 See more merch