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down syndrome 

a medical condition where the affected individual is missing a chromosome
why does my friend have different facial features to my other friends and me?

he has down syndrome but is still very beautiful
down syndrome by georgefaxel September 23, 2020
Related Words

Down Horrendously 

This mofo
Person 1: dude school has me fuckin tripping these days, idk how I’m gunna finish all this work
Person 2: At least you ain’t Tien
Person 1: facts actually, im guess im not down horrendously
Down Horrendously by Yelex January 20, 2021

Down Clown 

A heroin addicted loser.

A Slang term for heroin is down.

Usually lives at shelters, in tents or at the city centre bus stop.

Hobbies of a DOWN CLOWN are:

picK-pocketing; thieving from family; pawning childrens toys/games/clothes; nodding off anywhere and everywhere; drooling; not showering; boosting meat from Safeway; aggressively demanding spare change from young families and business people.
Kid asks, "mom, what's wrong with that dirty man at the bus stop? He yelled at that lady for money then fell over and peed himself!" Mom's reply, "oh honey, that's just a DOWN CLOWN. that's why it's important to stay in school dear!"
Down Clown by alannabanana604 September 20, 2021

Down bad 

When you are so In love with and obsessed with the opposite sex
Caleb Ridgley was so down bad for aubrito that he made her his lock screen and pinned her on snap before they even started dating
Down bad by Senorwidebody April 8, 2022

Down Periscope 

A manner of applying the Arabian Goggles. You sneak up behind the person and lower your balls onto their eyes, while saying "Down Periscope!"
I snuck up behind Matt and gave him the good ol' Arabian Goggles, Down Periscope style.
Down Periscope by PTPablo September 23, 2008

down da hatch 

adv. doing something cool, like how you would do something off da hook, but this is better.
Exclamation. Something you yell
Note: you may freely add motherfuckin' between da and hatch
after something good: Down da Hatch!
Dude, that was down da hatch
down da hatch by Chucko May 18, 2008