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Duff

The action of folding someone, or knocking them out
“Man I’ll duff your shit
Oh shit, Amari got duffed
by Slump November 20, 2019
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Duff

A cocktail consisting of equal parts Cynar, Campari, and gin with a splash of soda and an orange twist.
"Hey bartender, I'd like a drink that's neither too sweet not too bitter."
" How about a Duff?"
"Perfect!"
by megadope September 20, 2023
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DUFF

Desiganted Ugly Fat Friend. A common acronym used in male cliques. Used to refer to the girl that the "hot chicks" bring along to distract the "Wingman" (every male clique has one, his job is to intercept the DUFF.) so the ycan have the more desirable males of the group.
"Dude, you sooooo got the DUFF tonight."
by TXwolfman817 February 24, 2009
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Duff

That girl is our duff
by confident black girl January 28, 2015
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The Texas Beto Duff Fluffer

The act of having a Thoroughbreed studding horse take Mr. Beto O. up his loose caboose. This demonstration requires an armed man dressed like Tonto to hold the reigns of the horse whle the every-willing Beto O. is mounted and studded. During this punishment of Mr Beto for his recent demonstrations of ignorance and lack of empathy, long time NRA member, William Duff will fire 10 rounds of bee bees at Mr Beto's genitalia to further excite the horse and Beto. At the moment of climax, Mr. Duff will begin the chorus of Pour Some Sugar on Me that Beto will continue until he collapses on the ground in total exhaustian. Tonto will offer a warm towel to Beto and escort him away from Silver the Studdly Horse. Optional: If avaialble, you may add a fully dressed look a like of The Lone Ranger.
After seeing some recent political nonsense from Mr Beto, I believe he must be punished and pay for his wrong doing by performing the Texas Beto Duff Fluffer
by Sonnyd2022 June 2, 2022
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Duff

To Duff Out; A momentary lapse in reality shown by a vacant stare into a world of blank.
You just duffed out!

Man sorry i didn't hear you i was totally duffing out.

I really duffed out on that one
by Tazan August 22, 2011
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Duff

That place on the human body (particularly the female body) where the body makes contact when sitting-down, i.e. the erogenous area of the butt.
I'll bet her duff is as sweet as candy!
by anonymous March 3, 2023
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