a person who has lost life. they say it can kill you the first time you try it...if it doesn't you will wish it had.
The most prettiest girl in school got caught up in tweak...she isnt so pretty now and she is really mean with big gashes in her face from picking at it and no eye brows cuz she must have got really bored and tweaked by herself...poor girl she will never be the same
by I dont care how they do it February 24, 2005
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tweak=freak out, jumpy, on edge.
Shell tweaked when Mike scared her.
by ATXmoneymike January 26, 2005
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Philadelphia's (Philly's) own slut.
The word "tweaker" is often used to describe a girl with sloppy, slut-like attributes, and is known for getting with a lot of guys. A tweak is a nicer way of calling a female a whore, and or slut, and a tweaker may get with more popular, or famous guys. The word "tweak" is also used and is just a shorter version of the word "tweaker".
Malik: Yo, did you see Vanessa with Jamal last night? Yeah, she was giving him head in the back of the party, and everyone saw...
Kyle: Yeah, I know, that girl is such a tweaker.
Malik: Smh what a tweak.
by Olive_Garden69 October 30, 2011
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A small, long and narrow screwdriver, usually plastic, commonly used for adjustments to sensitive electronic components (coils, potentiometers etc)
"Hey Lou, pass me the tweaker, I need to make an adjustment here"
by anon-e-mouse April 11, 2005
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Tweaker: Boy/Girl tht go around fuckin everybody . Gettin passed around the whole team or city/place
Boy: there go tht tweaker over there
Girl: How She A Tweak
Boy: The Whole Team Was In Tht Bitch
Girl: Smh Fuckin Whore
by TweeterTweet December 21, 2010
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shane any guy named shane is a definite tweaker and you should keep at least ten feet away
“that shane guys coming i hear he’s a tweaker go to the other side of the road
by shahsnabdm June 23, 2019
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The state in which one is constantly bugging out.
AKA; Dave Schiavoni
by Punquen February 27, 2019
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