A transitive verb where the direct object especially refers to someone's genitalia, especially a pussy. Used to say that you fucked someone with a great deal of force or intensity.
"Oh man, I went so hard on Kat last night. I murdered her pussy so good, she could barely walk the next day."
"Damn, you really murdered that pussy?"
"Yeah, I murdered her real good."
Person 1: Dude i fucking hate my mom i should murder her
Person 2: Go to jail pls get away from me go away omg stop get away im scared why are u breaking into my house pls dont hurt me