Someone using Crystal meth or ice are referred to as tweakers. They are commonly referred to as tweaking out as in a state of paranoia or moving and twitching profusely.
Look at the tweakers peeking out of the blinds.

Look ! That tweakers been down this aisle 17 times in 2 minutes.
by MizzuzKotzz×3 September 17, 2018
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a tweaker is someone who has been doing Crystal Meth for a while and feens for it and is always twitching. Some one who is an addict for Meth.
L. - damn nigga YU're girl is a tweaker aint she?
P. - Ya im going to drop that bitch soon, she fucking up and be doing too much for the dopey
L. - oh, yah how much, give her my number in that case.
by baddxbxtchxdopey August 7, 2010
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a female that is a whore or has multiple sex partners. Originated in Philly; used in Philly and parts of Delaware.
Jon-ayo she a tweaker. da whole crew hit dat!

or
Jay-yo why did u and yo girl break up? she was fine!
Jon-yeah she was fine but she was a tweaker
Jay-aw man!
by lilmamapullin April 2, 2010
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1. A person that's like a hoe

2. Some one who will talk to alot of females/males at once

3. Some one who's addicted to drugs
"Yo, you a tweaker for real"

"shut up tweaker!!"
by Philly Girl_14 June 20, 2009
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1. A person who customizes an operating system, a.k.a. MS Windows or Linux.
2. A person who speeds up their computer. See also overclocker.
1. You know Ken, always changing his settings. Such a tweaker, really.
2. Hey, that Dave guy burned out his CPU again, tweaked it too much.
by Toba September 22, 2004
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Someone who constantly worries about a situation and obsesses over the possible outcome of something before it happens. Someone who thinks a lot and dwells on things a lot.
I am worried about how my dress will fit, will he think I am fat?

Do you think I will get in to trouble? I am tweaking on the situation.

What will happen if the judge sends me to jail? I am a tweaker.
by kelsmaster August 10, 2009
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A word used popularly in Philadelphia, Pa to describe female dogs who get “smutted” around by a group of men. The men are either friends, cousins or even siblings maybe complete strangers but that's rare with Tweaks. Tweakers are often exposed on the Tweaker List page via Facebook. Tweakers are not aware that they’re tweakers, until they appear on the Tweaker List. However, 99.9% are still in denial after being featured on every list. You can always find a Tweaker on Broad & Olney, King of Prussia, and Franklin Mills. They're in there like swimwear.
Girl: I'm not a tweak, I'm 15 years old and I let 5 guys hit.
I only sucked 14 dicks this year. Yes, I'm on the tweaker page, but these girls just hating on me because I had sexual intercourse with their boyfriends.

Boy: Your the true definition of a tweaker.
by Never Lying September 14, 2010
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