Two Howard Stern clones who occasionally have their moments. But, for the most part, they are rather unfunny.
Q: Who are Opie and Anthony?

A: They are radio hosts like Howard Stern, just unfunny.
by jose_198 October 20, 2005
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Two mediocre personalities that are obsessed with Howard Stern. They are have little talent and even less originality. Originally on XM they had an additional subscription fee to get the show and signed up few thousand people. They are dying a slow death just like XM.
by Bukkake the porno clown November 8, 2006
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Serey opy
by Baiwin December 21, 2020
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New OxyContin that have an OP instead of an OC on them, made to deter people from abuse because they can not be ground to a fine powder, and gel up when you try to melt them.
Ive been looking all day... all I can find is some Opy Cotton
by juicyjay4200 September 5, 2010
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2 radio hacks that arent funny and copy howard stern. they also lie to their fans who are almost as dumb as they are. EXAMPLE: "free FM fucking sucks...thats why its free" that quote is attributed to anthony cummia in october 2005. he later went back to free fm with his less funny sidekick opie. they are currently losing in ratings on free FM to the spanish channel. they went to XM and nobody cared.
opie and anthony...who are they? oh they tried to compete with Howard stern just like Imus, debella, mancow, don and mike, dee snider, david lee roth etc etc and failed.
by baltok the rapist January 15, 2007
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To lather up with soap in the shower, only to turn off the water, exiting the tub covered in soap, then running out into the house and giving the nearest person a hug. Only then to put lathered soap on them, giving them a "Soapie Opie."
Man, I can't believe it. I was over at Frank's house and he came running out of the shower all naked and lathered up, then he gave me a Soapie Opie.
by markmanvan November 5, 2007
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street name for opium. what you say, not to get busted by fuzz
Hey Z, get your ass over to my crib and meet opie man.
by The Juggalo October 20, 2006
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