When someone is being an ignorant scumbag and is acting like an annoying grump for no apparent reason.
Jake: Hey broskie, wanna head to the fair with me in a bit
Chris: No bro, piss the fuck off!
Jake: Jeez man, Who got your balls in a knot?
Chris: No bro, piss the fuck off!
Jake: Jeez man, Who got your balls in a knot?
by James Mcagee August 6, 2024

She went to the crapper all bent over, like an hour ago, I bet she has a duce knot keeping her in there.
by Cooter polluter October 15, 2017

The instance when a females period blood clumps and drys in her pubic hair. "Its painful and gross."
"Fucking tracy, shes such a clot knot!" "I was late to work because i had to shower out my clot knots "
by pattytheinvisible September 30, 2014

An esoteric multiplex often heard as a "Not" by the wicked, but understood at great depth by the wise, usually used in complex preaching situations with other words that also have double meanings
by StillTrying2Help May 19, 2023

When you eat too much gluten or carbs and you get a pain in your abdomen and cannot stand up straight
by squiding January 13, 2017

When you have just done a booty bump of meth and engage in sexual activity, and your booty bump leaks out all over your partner's dick and causes him to not be able to cum.
Me: I finally convinced Gavin to booty bump with me, and you won't believe what happened!
Friend: What? Was it awesome? Did he cum?
Me: OMG, yes, it was awesome. But.....
Friend : Well, what?
Me: Well, my booty bump leaked out everywhere, and caused a huge mess. He stayed hard, but could never cum. Even after hours!
Friend: Shirley knot!
Friend: What? Was it awesome? Did he cum?
Me: OMG, yes, it was awesome. But.....
Friend : Well, what?
Me: Well, my booty bump leaked out everywhere, and caused a huge mess. He stayed hard, but could never cum. Even after hours!
Friend: Shirley knot!
by poirotgrl July 21, 2019

Jeff hooked up with this nasty chick that convinced him to go "Salloon Knotting" with her and all he remembers is a bottle of champagne with everyone laughing hysterically at him when he got a erection from her wiggling the bottle around in his ass.
by Maniconwords February 12, 2025
