The Matthew Perry combo is when you get high on both ketamine and buprenorphine at the same time. (His previous heart/artery issues combined with this combination is what caused his death, not the combo itself). You will indeed get zooted off your ass if you take this combo, and is a phenomenal concoction of scientific wonders that will take you from the 3rd dimension to the 3.5th dimension.
Dude, my friends and I took the Matthew Perry combo last night and got fucking blasted. Those buprenorphine strips are weak as fuck though, so we had to double down. Weak ass fucking government opioids, next time we'll have to try the lil peep combo.
by Dfenley December 8, 2024

by DeepFriedBalls October 27, 2021

by Your nan and her cat November 26, 2020

"Yo, I just took a Wombo Combo!"
"wtf does that even mean?!?"
"I just took codeine, and drank a fuck ton of alcohol bro"
"wtf does that even mean?!?"
"I just took codeine, and drank a fuck ton of alcohol bro"
by Little_Dark_One September 23, 2021

abbreviated as DC, a disabler combo is a combo that is almost a touch of death combo but not. it effectively disables your enemy's ability to tank because it drains their hp in such a way that a few more hits will kill them.
by pejafme June 24, 2021

by _redac October 8, 2020

by TopHatAK August 10, 2016
