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Typically a gender-neutral term by YouTubers simply used to group up all viewers, and greet them as one, big group used like this: Hey guys..and so on. Some think it is offensive, but this argument can be defeated in two ways.

1: If so, then why do so many people use it?
2: Girls typically have no problem with this.
3: Saying guys and girls is oddly strange.
Hey guys!
2: Hey, that’s not gender neutral!
3: Please stfu.
guys by QuiteSeriousDefinitions August 4, 2021
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something that those clickbait youtubers say every 5 seconds
"WHATS UP GUYS, WELCOME BACK TO ANOTHER BANGER OF A VIDEO GUYS"
Guys by riddim222 March 2, 2022
A gender neutral term to address a multitude of individuals at one time
Hey guys, who's keys are these?
Guys by MegatonDon April 10, 2024
Used by Gen Z in public conversation to virtue-signal their submission to whatever they think people want to be addressed as; a catch-all.
If said by a sit down fast-food waitress with nose-piercing and blue hair, “Are you guys OK” means, “don’t forget to leave me a tip”.

If said by a universal congregational minister, “I pronounce you guys man & wife”, it means that he /they/she/zhe is being non-judgmental.
Guys by Mr. Dhoy December 28, 2024
The salutation at the beginning of your sentence to address your interlocutor when talking to 2 persons or more
Guys, did you catch the latest episode last night? It was epic!
Guys by Emotional Cruiser November 26, 2025
-“Guys!”
-When that broad texted me I straight up said guys!
-Her tits were so nice I just said guys.
-When Rupi and his boys showed up to the crib looking woke AF we all said guys.
-When I saw my boys at the club everyone just said straight up guys.
guys! by GerthPaul December 3, 2020

“Guys....” 

When you’ve either crapped your self or done something
*throws a rock and hits a window*
“Guys....”