1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
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Bradley was tweaking after he took crack
by Bradley Fox February 1, 2018
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Dude, all I said was "hi" and he started tweakin'! What's his deal?
by Anonymous April 19, 2003
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1. Customise or modify (something) to suit a particular individual or task
2. Improve (a mechanism or system) by making fine adjustments to it

synonyms: adjustment, modification, alteration, change, adapt, customise
I am going to tweak the design a little more on photoshop
by eslupmaet June 16, 2014
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To space out intensely while under the influence of some sort of psychotropic drug.
Guy 1: *spacing out, drooling*
Guy 2: what's wrong with you?
Guy 1: huh?
Guy 2: Dude you're tweaking.
by Fishmanist January 9, 2010
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It's YOUR brand, do what ya' gotta do!
Dude, I helped TWEAK design a shoe!

The TWEAK Rhett & Link Mythical Shoes are the coolest shoes ever check them out!
by TWEAKfootwear April 4, 2011
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