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Who are you, and what have you done with 

Used to express astonishment when somebody says or does something completely out of character. The only possible explanation is that they've been replaced by an alien shape-shifter who looks exactly like them, but acts differently.

The phrase is a parody of the cliché found in old movies, when somebody returns home to find their lover gone and a stranger in their place.
Shanee: "I'm going to stay in tonight and study."
Ruthie: "Who are you, and what have you done with Shanee?"
Related Words
done done up donezo döner doned doneski done in donegal donell Done Goofed

What has science done?

An internet meme which is often used to describe something extraordinary, commonly a rare creativity which has a relation to science as a whole.
Person A: Hey, look at this: *link*
Person B: What is it?
Person A: Look for yourself, I call it the multitude-bathduck-replicator
Person B: WHAT HAS SCIENCE DONE?

been there, done that 

An expression used to say that one has been in the situation or experienced that which another is talking about. It is usually a negative scenario that is being discussed.
1: Damn, I forgot my homework at my house!
2: Been there, done that.
been there, done that by JoMan112 January 28, 2011

"We are done professionally." 

Used to address the end of the line in an escalated conversation, debate or exchange. A loss of temper or patience is often the catalyst.

Made famous by actor Christian Bale's infamous outburst on the set of Terminator Salvation.
"I think Sarah Palin got a bad rap in the press."

"Are you kidding?"

"Seriously, she's a terrific role model for women."

"We are done professionally."

sammi done

When you aggressively claim to be done with a relationship even though everyone knows you aren't.
I can't deal with this anymore. I can't deal with him cheating on me anymore. I am done." "You're all talk. You are only Sammi Done.
sammi done by funstigator September 10, 2010

Gettin Shit Done 

1. To finish a task that has been troubling you for a long period of time.

2. The act of driving over the highway wall in GTA: San Andreas to escape the fuzz.

3. To purely own someone in a fantastic manner.
1. Don: Oh hell yeah! I finally finished my math!
Bill: Damn dude, yer gettin shit done!

2. *Drives over highway wall* Don: Check that shit out!
Bill: You most definately just got shit done!

3. Bill: *kicks kid in mouth*
Don: Whoa! You just got shit done!
Bill: Oh hell yeah.