tweaker 

basically an hore or slut a female who has sex with many guys

yo you know dat girl down da street?

yea man she a whole tweaker

tweaker by dabullty December 9, 2009

Tweaker 

A low life piece of shit who feens hard for meth and other drugs and cant keep their shit together

"You see that guy over there?"
"Yeah! What's he doing with that air duster?"
"Idk think hes a tweaker"

Tweaker by HelpFul Definitions January 13, 2016

Tweaker 

Slut,whore,yooker,bobblehead

Your girl is a tweaker everyone bust her ass

Tweaker by jkgggk September 19, 2009

tweaker 

one who 'tweaks balls' as in one who uses the drug methamphetamine to get amped and then shakes around and talks non-stop.

I would have asked Mary to help me study for my test but she's such a tweaker --she couldn't sit still for more than 2 minutes so that's why I got a D+

tweaker by brandon December 3, 2002

tweaker 

a whore, a promiscuous female who engages in sexual activity with a lot of people who they have no relationship with.

"man, she'll let anybody hit, she a tweaker."

tweaker by k_milly May 11, 2009

tweaker 

Someone with a methamphetamine who is usually a theif.

That fucking tweaker stole my lighter

tweaker by Dzay June 22, 2007

Tweaker 

Someone using Crystal meth or ice are referred to as tweakers. They are commonly referred to as tweaking out as in a state of paranoia or moving and twitching profusely.

Look at the tweakers peeking out of the blinds.

Look ! That tweakers been down this aisle 17 times in 2 minutes.

Tweaker by MizzuzKotzz×3 September 16, 2018