(1) to act like a spaz (see spaz) (2)to be incredibly hyperactive to the point that people believe you to either be mentally insane or hopped up on something (while not under the influence of drugs)
Did you see how Doug was tweakin' the other day?
by JK April 3, 2005
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1. a person who is tweakin out from crack
2. a crack baby
by Krysti Moaner April 11, 2003
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to fucking snap! to feel like you have been through enough bull shit and you just want to hurt someone
my girlfriend was putting me through so much shit last night i was ready to fucking tweak
by Kevin Bowen September 12, 2007
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(or tweek) To slightly adjust one's computer in order to increase it's speed. Often associated with overclocking.
I've loved to tweak the shit out of everything ever since I started messing around with computers.
by Zamfir June 18, 2004
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Verb. To deliberately provoke, to push someone's buttons.
"So I said, 'how many feminists does it take to change a light bulb?' She said, 'How many?' I said, 'Three. One to take out the old bulb, one to put in the new one, and one to suck my dick."

"Did you do that just to tweak her?"
by Danny Delinquent December 5, 2003
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1. To prefect something
2. Used to replace cool or related words in a sentence as an adjective

1. I totally tweaked my kickfilp today
2. Man thats party was tweak as !
by Ev-Dawg October 2, 2007
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verb. to play with a girl's tit until it stands up.
example: tweak me, baybay!!
by tosachi April 11, 2008
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