Tweak 

(v) to tweak: a high resulting from methampetamines

He's the biggest druggie, he tweaks everyday.

Tweak by Cacoo June 26, 2003

Tweak 

1. To adjust accordingly
2. To freak out

1. His guitar sounds like shit 'cause he's gotta tweak his amp.
2. When she heard me play my guitar she tweaked.

Tweak by Buzz Cola October 23, 2003

Tweak 

Really jumpy, talks with his hands, basically the baddest mofo on a campus near you.

Look at tweak walkin outta math class.

Tweak by snaggatoof February 6, 2010

tweak 

1. to adjust slightly

2. to adjust a computer program slightly

They tweaked the game to fix a glitch.

tweak by Light Joker September 2, 2007

tweak 

v- to tweak
to be extra twitchy, secretive, giggly while under the influence of weed, pot, marijuana
to have the tell-tale signs of being high (squinty eyes, blood-shot eyes)

"Yo after taking those five rips off the bong, I was totally tweaking out. I was pulling my hoodie all the way down, I put sunglasses on, and my eyes were BARELY open"

tweak by bnell9002 December 28, 2005

Tweak 

To adjust or fine tune things, to personalise an object and make it better to suit one's liking

Holly was eager to tweak her sister's white canvas slip-ons with rainbow unicorns because she knew they were her sister's favourite mythical creatures.

Tweak by fln September 23, 2013

tweak 

Computers: To slghtly alter various settings and configurations for customisation and improving performance.

You can get better framerates in the game if you tweak some settings.

tweak by generic January 21, 2004