Up-syndrome

A person who is seriously ugly to the point no one wants to look at them without protective goggles.

That guy has up-syndrome, he’s such an uppy

by Lickle bump February 25, 2022

Up Syndrome

When someone tends to hover above chimneys

Dolly has up syndrome, look at her hovering

by Dick Massive June 30, 2021

up syndrome

when you have so much down syndorme it inverts itself

"jozlen sussy jol" up syndrome

by jolzen December 1, 2022

Up Syndrome

When you get filthy rich in the trenches and retire your parents

cupsey got up syndrome

by probably trenching March 4, 2025

up syndrome

when your syndrome is down but your money is up

"my syndrome may be down but my money is up, And that's why they call it up syndrome,,

by the big fat rat November 13, 2023

Up syndrome

you say it to insult someone

you don't have down syndrome you have Up syndrome

by MangoMane January 25, 2025

Q Up Syndrome

A term used for League of Legends players when they say "queue up," or play another game, when the player(s) is not mentally, emotionally, and/or financially stable. This act promotes both sadistic and masochistic characteristics to themselves that they are aware but ignorant of because LP addiction is more powerful than society. This condition is chronic and could lead to brain damage.

"I can't take it anymore... I'm going to Q up... ARUGHHHHH," Yerpyyy said.
"Yeah you have stage 4 and Q up syndrome," Mars replied.

by Yerpyyy July 14, 2023