Your Sister's a mister

The ULTIMATE Insult To end anyone's career in One saying

Your mom Gay Lol
While Your sister's A Mister

by Samuel_Le_Jackson May 21, 2018

mister-sister

Someone of the male species, that wants and or appears to look like a female.A male that is very feminine, also known as a "shemale"

That gay guy looks like mister sister

by Nicki November 10, 2003

mister sister

a transgendered person

Chet: That girl looks awfully masculine
John: Haha Chet, that isn't a girl, that's a mister sister
Chet: A what?
John: A mister sister. A shemale. A tranny. You gettin' it?

by SHMOSEPH May 8, 2013

mister sister

A drag queen.
Origin: "Will and Grace"

Don't mess with that mister sister, or you'll end up looking like a Cher barbie doll gone bad.

by asdfghjkl September 25, 2006

Ur sister a mister

You do not want anyone to say this to you. This is the best roast in the entirety of all roasts. Worse than ur mom gay, ur dad lesbian, ur granny a tranny and ur grandpap a trap combined.

Lobster: Yo ur mom gay and ur dad lesbian.
Egg: No u.
Lobster: No u x3.
Egg: *OOF* Well ur sister a mister.
Lobster: *gets engulfed by the sun and dies*

by eat_my_lasgagne_bitch69 March 18, 2018

ur sister a mister

An insult more powerful than "ur dad lesbian" but not as powerful as "ur granny tranny"

"ur dad lesbian" Jerry said to Leo
"ur sister a mister!" Leo responded
*Jerry dies*

by Grendman May 14, 2018

your sister a mister lol

One of the more gritty underground roasts, please use with extreme caution. May cause recipient to go into an anaphylactic shock, epileptic fit and or straight up seizure. Other side effects which have been known to be a consequence of this insult includes full-blown autism or an addition of a chromosome.

Sarah: Your mother is a child-beating, cheap whorewho has achieved nothing manage to trap a man to have a child with her, a massive mistake... you. That mistake is you, you unloved virgin.

Janet: your sister a mister lol

Sarah: *Develops autism and literally fucking dies from her throat closing up*

by Joey Gobbless March 24, 2018