Loo Share definition Flag A slang for 'L-O-L' (Laughing out loud.) Created by sloppy typers, pecking at keys. anyuser007: ...And then he totally fell on his face! kitty0325: OMG, LOO! Loo by PhildotheGreat April 21, 2007 0 0 Get merch Get the Loo mug. Buy Now — $32.95 See more merch