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G's up, Ho's down 

Ecstasy pills with the letter G with a dot on one side and a chick on the other. If you in Jersey and got this be aware that it is most likely MDA, not MDMA. Check MDA out on erowid and check ecstacyinfo.org (search for "g" and you'll see and entry for Newark, NJ which says it was tested positive for MDA).
"The dance is Saturday and I just got hooked up with some G's up, ho's down."
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G's up, Ho's down  

G's up, hoes down, while you motherfuckers bounce to this

snoop doggy dogg-Gin and juice
G's up, Ho's down
GSI stands for G String Invaders also known as the IMEA (International Male Escorts of America) is an exclusive male escort assosiation founded by CEO Mr.Mandingo aka Adonis and Co founded by Mr.Tripod aka Pop Tent. The founders go by many names including The Lumber jacks, The Old Spicemen, The Wrecking Crew, The Demolition Crew, The Fire Crew, Nights of the 209, Adonis and Pop Tent, Mandingo and Tripod, and IMEA. They're slogan "The customer always CUMS first" is guaranteed. GSI is exclusive and is held to the best standards. Bestvdamn service you will ever get GUARANTEED.
Crystal: Omg so i orderd these guys called G.S.I. and they fucking wrecked my chasm and spooged all over me. They're slogan "The customer always CUMS first " wasn't a joke. I think im gonna call them again.

Nicole: Damn girl whats they're number??? I want to my fucking pussy filled that good too!
G.S.I. by Pito Gainer August 3, 2014
Gay sensory perception a.k.a. gaydar. The ability of gay people to determine others' gayness without discussion or apparent evidence of it. G.S.P. often is set off by eye contact.
The new chick in the office totally set off my G.S.P. When we looked at each other her eyes were like, "Yes, I am."
G.S.P. by Capt. Jack Sparrow February 25, 2004

G.S.A.L.O. 

G.S.A.L.O.- Go suck a long one. Could use it to tell someone to shut up
Adrian: hey Greg, when u gonna come and fix my house

Greg: G.S.A.L.O.
ADRIAN: what?
G.S.A.L.O. by AAR0511 March 2, 2015

G.S.A.G.R.A 

Acronym for Go Suck A Gay Rhinos Ass.
" Joe texted me G.S.A.G.R.A So I'm going to Fuck his sister."
G.S.A.G.R.A by 69disan69dat November 29, 2020