Hoe Share definition Flag a girl that gives up the goods to guy that doesn't deserve it. A female that fucks wit the homies of her current or ex boyfriend. Nani is the hoe of Science Park High School in Newark,New Jersey Hoe by LOL IMLFAO March 11, 2010 0 0 Get merch Get the Hoe mug. Buy Now — $32.95 See more merch