To be High and Drunk at the same time. In other words, Twisted, but in an excess amount. You get Smurfed by drinking and getting highmore than the normal amount. Being Smurfed can lead to righteous partying and having the best time of your life.
When you are having sexual intercourse doggy style in a port-a-potty and as your ready to climax you shove the girls face in the blue solution in the bottom of the toilet causing her whole face to turn blue.
When a man covers his penis in blue food coloring, and has sex with a woman, causing her to slowly turn blue from the inside out. The man will often exclaim after ejaculation, "You just got Smurfed!" and immediately run out of the room, never to be seen again.