International Space Station.
A space station that has succeeded the Mir (Russian) Space Station. Has been in assembly mode since 1998, and delayed several times. The I.S.S. is made up a consortium of 16 nations, including Japan, USA, Russia, Brazil, Canada, and the E.U. (European Union).
The ISS will be complete in approximately 11 years.
by JPWRana September 18, 2005
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person 1-What ya doing?
person2-Itching my balls
person1-Argh of course ISS
by twatnose September 6, 2010
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It Still Sucks. A short way way of telling someone that they fail, again.
Person A: I re-recorded the vocals for this song.

Person B: ISS.
by Shot Shiffith November 19, 2009
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In School Suspension, also known as OCS, On Campus Suspension. A beggining for punks or delinquents, the first stop before alternative school and eventually jail.
"Shit, man, I got another four days of ISS."
by Styk Stoker April 25, 2004
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A complete idiot of a sort. Lacks to acknowledge the value of education. Someone who overplays WoW(World of Warcraft)
Please don't let your children end up like a isse
by hehehohohahahuh February 25, 2009
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"I'm so sure!" said like a Valley Girl. (see also the movie Clueless)
He told you that you looked fat? ISS
by GoodUncle April 3, 2013
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Itchy Scrot Syndrome
A non-contagious condition wich has seemed to spread throughout the northe east of england and is rapidly spreading across the world. Thought to be caused my shaving of the region or just over "use".
George: Hey man
Ben: Hey
George: Hows it going
Ben : Ahh I think I have ISS
George: Unlucky man, put some ice cream on it
Ben : Good Idea bro, Peace
by Jelly Man April 20, 2008
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