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Tweaking 

Someone who is really high on ice or meth!!!
Damn that dude is tweaking balls!
Tweaking by Realfunni February 24, 2019

Tweaking 

Omg she’s tweaking, she must be hallucinating.”
Tweaking by Vatrinna March 16, 2021

tweaking 

Dude, you are totally tweaking.
tweaking by Epigone July 1, 2003

Tweaking 

To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
Tweaking by HondaKiller2TGR June 18, 2008

tweaking 

when someone is acting a weird type of way for no reason at all.
Yo, why is you tweaking? I didn’t steal your shit.
tweaking by lilshitstain January 16, 2019