1) Short for sister
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
by wxynot July 31, 2005

Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
by ChocolateWafflez April 15, 2015

Abbr. for 'stupid idiot'
by Nige Menzel June 11, 2007

the abbreviation of "sister";
a genderless term much like "bro" or "dude"
people can also say it like "sister" but that doesn't change the definition
like when you say "brother" instead of "bro"
a genderless term much like "bro" or "dude"
people can also say it like "sister" but that doesn't change the definition
like when you say "brother" instead of "bro"
-"How do you feel about celebrity drama?"
-"It's the tea, sis."
-"Hey sisters!" -James Charles
-"How u doing?"
-"I'm so fucking depressed, sister"
-"It's the tea, sis."
-"Hey sisters!" -James Charles
-"How u doing?"
-"I'm so fucking depressed, sister"
by Bakuhoe Katsubitch January 9, 2019

Suffix added to the end of almost every word. Used mostly by 40 year women talking to their children and/or dogs, or drunken college whores in a desperate attempt to sound more cute, less riddled with STDs and premature, substance induced age.
by Ihateyouallsomuch July 31, 2005
