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Diffy in the jiffy 

Used commonly as slang in the modern videogame League of Legends, popularized by a Twitch streamer Tarzaned and many others, when one of the players in one of 4 lanes (Botlane, Midlane, Toplane, and Jungle) hardly underperforms in the Jungle role or gets outplayed by the enemy player several times, causing the game to be lost before 20-minute margin.
Yassou: Oh no! We have Nightblue3 on our team
Sanchovies: Diffy in the Jiffy it is...
Diffy in the jiffy by Chrive May 29, 2020
Mathemtician Slang:

A differemtial Equation.
Yo son, did you use the Wronskian on that mutha fuckin' ass diffy-q?
diffy-q by Skandal Jack May 13, 2005
Mathematician slang for differential equation.
Doood! Diffy-q's are suck!

Translation: I'm stupid.
diffy-q by meselfs January 11, 2005

diffy in the miffy 

When someone can't hang
I challenged some fools at a Party to a round of Beer Pong and they started started throwing up after the first 5 cups.
Huge diffy in the miffy!
diffy in the miffy by Aehrre January 30, 2022

diffy screw 

differential equations - the midway point in mathematics for most modern engineers
Once you're done with calc useless, you can take diffy screw
diffy screw by mouffpiece May 12, 2016

Diffy Gravy 

synonym for built different, but sounds cooler
- Matthew just hit 1 million subscribers!
- Oh, nice! He is diffy gravy!
Diffy Gravy by sennx_ February 14, 2022