cee•tee•eff•oh. interjection. An expression of disappointment or disgust at the idiocy, douche-baggery, or general reprehensibility of others, acronimized from "Come the f* on."
"Did he really think we wouldn't notice that he copied two whole paragraphs from Wikipedia? CTFO."
Man1. Mr Salad is doing his nut again, what did you do to him this time?
Man2. Me? Nothing, he caught his baldy half inch roll back in his flies.
Man1. It's funny as fuck when he CTFO.
Man2. Word.