When your trying to be a bad ass, and drink so much alcohol you projectile vomit.
Also, You're a wingman on a date, and your job is to lay on the grenade, meaning take one for the team, meaning date the not so hot friend, and you drink so much to make it happen, you accidentally puke on them.
Also the name of a DJ in Florida named Puke Grenade.
Dude, quit trying to show off. You're gonna pukegrenade everyone.
A sworn oath made by a person out loud into a toilet in between uncontrollable dry heaves and torrents of vomit, offered as negotiation with God if He will end the pain.
"I puke promised to stop jackin off to nasty shit, but I threw up like four more times."