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What's that? 

1. Another way of saying "what did you just say?", or asking the speaker to repeat their previous statement, due to lack of volume or attention or volume.
Synonyms: Huh? What? Whu? What did you say?, say again?, you talkin' to me? etc.

2. The question asked by youtube haters, cyber thugs, and internet toughguys when they first see a girl naked at age 45.
1. Matt: "I heard Dave knocked out Bruce last night and took his dope."
Vinnie: (paying attention to something else) "What's that?"
Matt: "I said, I heard Dave knocked out Bruce last night and took his dope."

2. (Paid-up-front-hooker removes her panties before youtube hater)
45 year old Youtube Hater (pointing to the snooch): What's that?
What's that? by BHK on Vernor April 22, 2009

That's What's Up 

A way of agreeing to what the other is saying. Or if they ask you a question it can also mean that you are down to do what they're asking.
1:"Ay mayne, i got this killa, we blazinituptoday?"
2:"Shiiiit, that's what's up!"

What's that BTA? 

code for: What's That Bitch Talking About?
What's That Bitch Talking About is a spoof game show featured on Saturday Night Live when Tina Fey hosted. The title can also double as a phrase used in conversation or in the classroom when an annoying person or teacher says something unbelievable and/or difficult to understand. It is said in code so the person being referred to as "bitch" is unaware and therefore not offended.
Teacher: And then you calculate a 95% confidence interval predicting the population proportion using the sample standard deviation and hypothetical velocity.
Bob: Dude, what's that BTA?
Rob: I have no clue man.

or

Girlfriend: Joe you said you'd call me in the morning when you woke up!
Joe to friend: What's that BTA now?
What's that BTA? by McGlovan February 26, 2008

that's what's up 

Something that is exciting, great, and agreeable.


cool the shit the bomb These are just a few synonyms.
that's what's up by dd3953 December 30, 2008

that's what's up 

Originated in Philadelphia circa 1998. When discussing events that are of intrest to both parties. The person that didn't know what was going down would say that's what's up.
usally rhetorical.
Frank:Yo! There's a big concert at the spectrum tonite?
Jonny: that's what's up!
that's what's up by HRM SMK April 2, 2008

What's that pizza sayin' 

When one is concerned about the integrity of said pizzas and airs the concern with the owner , so to speak , of the pizza.
Person 1: what's that pizza sayin'
Person 2: it's pepperoni from rios down the road
Person 1: *high pitched laughter* ye lad init