Up Syndrome

a condition of extreme smartness

"I'm so smart I have Up Symdrome."

by tug July 9, 2003

Shut the fuck up syndrome

When someone won't stop talking oh my god shut the FUCK UP

"blah blah blah blah blah blah blah"
'Shut up! You have critical shut the fuck up syndrome right now!'
"Oh, sorry. blah blah blah blah blah"

by chazwolf_ November 15, 2020

up syndrome

having the disorder that makes you tie one octillion balloons to your house daily

up syndrome isnt the opposite of down syndrome

by brian33337 October 14, 2023

up-syndrome

The condition where genitalia is in a perpetually happy state.

"Tom came down with a case of up-syndrome soon after meeting Caroline."

"We always thought Susie was a bit weird, but we didnt know for certain until her secret reared its ugly little head -- she was diagnosed with up-syndrome."

5:00 News Report:
"Rare condition found in man with up-syndrome... Are two penises better than one?"

by PetShelterPimp March 5, 2005

Butt-up syndrome

When a person is sick and when they go to use the bathroom to take a dump, a sudden urge of vomiting arise and with no to wipe, flush, and pull your pants up, they get on their knees and vomit with their naked butt up in the air.

My mom caught me in the bathroom with butt-up syndrome. She asked me "Saba why do you have your pants down when you are vomiting" I replied, "Because I didn't have time to wipe and pull them up!"

by Da Beast from the Middle East May 1, 2009

post break up syndrome (PBUS)

when ur so bummed about just bein dumped by the person you loved, that you start acting like a total retard

"hey evrybody listen to this" (bends over and farts)

by giz May 24, 2004

Up syndrome

When someone is so retarded they have "up syndrome" instead of down syndrome

yo mama so stupid she has up syndrome

by A_Walking_Meme June 18, 2019