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"That is off the hook for real" would be the literal meaning of the phrase. It means that something is extremely novel and interesting, and that you're dumb enough to think you sound cool adding "izzle" to the end of your words.
Dude A: Hey dude, have you seen Frank's new car?
Dude B: Why yes I have. That tizzle off the hizzle foshizzle.
Dude A: WTF?!?!?!
by Rosekelly June 22, 2008
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What you say when you are surprised and dont have words to say.
Bob: "What's up dude?"

Mike: "fo-shizzle my nizzle off the hizzle...drizzle." If it isnt Bob!"
by iamyoursandwich January 3, 2013
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i am not needing a bj right now. come back later u nigga.
Hey billy. Jimmy says "Bounce ur shizzle off his hizzle my nizzle!" he wants u latta.
by ur mom May 6, 2003
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Snoop Dog speak for It's off the Hook my brotha!
Snoop, how cool was that party?
"It's Off the Hizzel fo' Shizzel my nizzel"
by The Docta April 29, 2003
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