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Typically used on the east coast from Georgia down to Ohio. Taking off essentially means that you have just taken several hits of a joint. Take off is the act of getting stoned.
Person 1: “hey bro do you wanna take off right now?”

Person 2: “let’s do it man, let me grind these bud and roll it bro!”
Take off by Twotenor December 21, 2021
A word that used in mw2new
In Chat: TAKE OFF NOW NO W

Take off!  

a Canadian phrase that was made popular in America with the 1982 winter hit "Take Off!" by Canadian comedians Bob and Doug MacKensey. Geddy Lee of Rush provides the actual singing between the "verses" that are pretty much spoken by the comedians. Bob and Doug would go on to more success with their Christmas hit, the movie "Strange Brew", and more.

Take-off 

1. The moment when a mind-altering substance begins to act in one's system.

2. The onset of the effect(s) of a mind-altering substance after its inhalation, ingestion or injection.
Dude, you'll definitely take-off before you finish smoking that giant blunt.
Take-off by m-fun December 15, 2019

take off your armor 

Medieval sex term for taking off your condom, used in the ye ole days when banging unprotected.
The king said," Take off your armor"
"I like to live dangerously"

Take off every zig 

What one does upon discovering that all one's base belong to Cats. Often done for great justice.
Take off every zig by BCal November 18, 2003