PGR or "Prettiest Girl in the Room" Disease is a condition that afflicts attractive women everywhere. It's characterized by the negative reaction a pretty girl expresses when she meets a girl that's prettier than her, rendering her "not the prettiest girl in the room" anymore.
Girl 1: Mandy, you look lovely as always. I'd like you to meet my friend, Sexy Withoutmakeup.
Girl 2: I don't like her.
Girl 1: You just met her, why not?
Girl 2: She's dressed like a whore.
Girl 1: Oh, you're just being jealous. You've got PGR Disease.
Girl 2: I don't like her.
Girl 1: You just met her, why not?
Girl 2: She's dressed like a whore.
Girl 1: Oh, you're just being jealous. You've got PGR Disease.
by rhastings88 March 3, 2014

A literature phenomenon in which the first book of a series does so well, and may even be considered a classic, that subsequent books in the series become staggeringly formulaic, to the point where the only difference between it and the last one are maybe location, names of characters, and point in time the story takes place in.
Named for Piers Anthony, author of the Xanth series, one of the most notable instances of this phenomenon.
Named for Piers Anthony, author of the Xanth series, one of the most notable instances of this phenomenon.
"I really liked Frank Herbert's "Dune". It was honestly a well written story, its just that his other books got quite... similar afterwards. Same general plot, message, almost everything but the names."
"Ah, so he contracted Piers Anthony Disease?"
"I'm afraid so..."
"Ah, so he contracted Piers Anthony Disease?"
"I'm afraid so..."
by RadienX Chaosmaker October 3, 2019

by BARBARAH January 6, 2022

lexie: i haven’t drank water in a week but i have drank lots of milk
abi: omg lexie, you have milk disease!
abi: omg lexie, you have milk disease!
by milkymoo February 7, 2020

When the Pokémon Jess has spread her sicknesses though technology and Air the way to cure of this to contain her or take care of the sickness you have of it
by Jessfallenangel September 17, 2019

by Kemistry🌟 May 28, 2024

It says in the Bible, when a man or woman chooses to act and dress like the opposite gender, it is an absolute SIN and considered a MENTAL DISEASE
by unknown604 May 13, 2024
