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A cheap malt liquor/beer popular in the ghetto. The Faygo of beers.
I wanna get drunk, but I'm short on cash. I'll just get some Colt 45.
Colt 45 by Drunk Tightwad October 10, 2008
Related Words
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US Government, model of 1911 pistol, cal .45 ACP 

Brainchild of the legendary arms inventor John Moses Browning, it is a single action, short recoil operated, magazine fed auto loader. This venerable pistol had seen service in the US armed forces for 85 years since its official adoption in 1911. Originally chambered in the new (at the time) .45 ACP (automatic Colt pistol) The .45 "Auto" cartridge is a direct descendant of the much older .45 COLT revolver cartridge. The pistol was beginning to be replaced in the late 1980's by the Beretta 92f (M9 military designation) chambered in NATO standard 9x19mm. The 1911 pistol still remains popular in military service in special forces detachments such as Army Rangers, Delta and certain US Marine units. This pistol/cartridge combination has been battle proven as a very tough and reliable military sidearm. The Vietnam war wound studies of US military trauma surgeon Dr. Martin Fackler have revealed that the .45 has excellent terminal ballistics even in a military 230 gr. hardball round. In the civil market this firearm and newer various clones remain one of the most popular pistol types particularly for concealed carry and defense.
I choose .45", "because needing to shoot twice is just silly. " "US Government, model of 1911 pistol, cal .45 ACP is the only pistol I will ever need!"

COVID-45 

Also known as COVID-19, Trump dropped the ball. The stock market crashed. City's and schools shut down for weeks. Unemployment went up to 3 Million.

Trump blames China and past administration's.

It happened own your watch 45 so own this shit!
Bro, the media call it COVID-19 because it surfaced in 2019. Fuck that it's COVID-45 because Trump is the 45th president.
COVID-45 by Polymath72 March 27, 2020
A malt liquor. It'll get ya drunk!

A single action semi-automatic handgun, otherwise known as the M1911, made by Colt. Chambered in .45 ACP, it has seen service from WW1 to the present day.
We passed the Colt 45 around until we were all passed out.

He drew his Colt 45 and shot him in the face
Colt 45 by Vaughn Proctor September 24, 2008

The Office, season 7, episode 19 minute 14:45 

Should have burned this place down when I had the chance.
Random grandparent: so how was school?
Susan: The Office, season 7, episode 19 minute 14:45
a cigar which is made from tobacco and marajuana, soaked in malt whisky and then dried to be smoked
if u want a cigar with a bit more of a kickthen a B 45 is ur answer
B 45 by Sam .f June 1, 2003