duff 

Duff (duff) v. To leave.

"We saw her boyfriend at the bar and had to duff"

duff by Dan Tucker December 2, 2003

duff 

To duff. (v)

1) An unspecified act, with the ability to surface in the conversation with vague initialization; a general verb replacement, adding emphasis on the action done.

2) The action/s brought upon in the rare situation of a peg-leg and/or amputee impaling another person’s chest at high velocity, generally in the process of a high-altitude attack.

1) a. "Dude, I'm totally going to duff you in the face if you don't shut the fuck up."

b. "Oh yeah? Well I duffed your mom last night."

2) (In the context of 'Rules of Engagement')
"Yeah, I can totally see that little stubby girl duffing him in the chest."

duff by Jeff Ott July 23, 2008

duff 

The leftover remnants of meth after smoking. Or small crystals of crappy meth that can be found on tables, etc, in a meth user's home.

We opened to basement door and told Jeff's uncle it was time to go. He screamed "Do you want me to do this F*kking Duff, or what!!!!??" while pounding a table.

duff by StinkyPP August 8, 2008

Duff 

The asshole

That man takes it up the duff

Duff by yogybear June 2, 2009

duff 

Dumb, Ugly, Fat, Fuck.......... every girl has a friend like this.

that girl is friends with that DUFF chick

duff by Tin973 November 10, 2006

Duff 

Designated Ugly Fat Friend

I got drunk last night and slept with the Duff.

Duff by zeee! January 7, 2009

duff 

"designated ugly friend"

an ugly poor girl you use to laugh at. She has such a scummy pathetic life and drives a 2 dollar pos. Her face is ugly too. Her family is fucked in the head and she makes you feel better about yourself. Though you don't have to, she can make anyone feel better about herself since her life is such a piece of shit.

Boyfriend: don't call the duff tonight, she's too psycho to hang out with.

Girl: Don't worry, i won't, i don't hang with her anymore, it ruins me reputation.

duff by tawns02 December 9, 2008