When someone, usually when gaming, yells and screams at their screen. They're normally loud but doesn't have to be to class as jacksepticeye syndrome. Not to be confused with anything about loving jacksepticeye or being a fan.
by pseudony.com/index.html January 15, 2017

A typical malaise affecting those who live in secluded rural areas such as Lincolnshire, England. Symptoms include lack of urban awareness; an aversity to progress; general social/racial ignorance and crucially the inability to accept that such areas are generally shit. Sufferers may find difficulty in rehabilitation; some have been known to live in said areas for life due to their irrefutable lack of ambition. Surprisingly some are content to be entertained lifelong by Young Farmers' parties and "Skeg-Vegas", an association of which the true Vegas, thankfully, is unlikely to know of. To this date there is no apparent cure.
by pradzor March 17, 2010

When one gets the peculiar urge to date or have sexual intercourse with those of East Asian Descent.
by Gpopper March 3, 2010

A common syndrome among osu! players when they see the number "727" a lot and/or see it on objects that don't even resemble it.
Person 1: Oh look it's an In-N-Out, wanna eat lunch there?
Person 2: WYSI WYSI 727 WYSI.
Person 1: What the fuck are you ok? Do you have WYSI Syndrome?
Person 2: Yes I need help.
Person 2: WYSI WYSI 727 WYSI.
Person 1: What the fuck are you ok? Do you have WYSI Syndrome?
Person 2: Yes I need help.
by Suguri- September 19, 2021

What President Obama develops when dealing with Republicans who hate his guts and want to destroy him. Similar to the well-known phenomenon known as Stockholm Syndrome, where hostages begin to relate to, care about, and defend the terrorists holding them captive, except in this case, you are the President of the United States.
Observer #1: "Fuck! Obama caved in to the Republicans AGAIN, even though he had all the advantages in negotiations! I don't understand it at all!"
Observer #2: "Barackholm Syndrome strikes again..."
Observer #2: "Barackholm Syndrome strikes again..."
by NCScientist August 1, 2011

This is when a fat or unattractive looking women believes she is hot and can have any man she desires.
The grenade is the less attractive of the women in her group. They often get approched first by men. As this is often the way the group of men initiate conversation with the group of women. Thus giving the grenade a false sense of popularity and attractiveness level. Aka grenade syndrome.
The grenade is the less attractive of the women in her group. They often get approched first by men. As this is often the way the group of men initiate conversation with the group of women. Thus giving the grenade a false sense of popularity and attractiveness level. Aka grenade syndrome.
My fat friend told me that she loves going out clubbing as she can get any man she wants. I dont want to tell her that she has grenade syndrome!
by Ro-Em June 24, 2016

A deep-seated defect of character originating in childhood, resulting from incompetent parents who are most often addicts who have neglected the child’s emotional needs and caused the child to shoulder the bulk of the responsibility burden, making them the de facto parent.
Yup, I can thank my Helper Syndrome for making me a world class chef, an incomparable race car driver and not least, a highly lauded prison psychologist and behavioral researcher, all before I reached the age of 10.
by Dr Bunnygirl September 14, 2019
