DUFF

Designated Ugly Fat Friend

If you don't know who the DUFF is in your group, odds are it's you

by KatLovesBands February 23, 2015

DUFF

Designated ugly fat fuck

Aye that bitch is a duff

by bigfloppykitty February 9, 2015

Duff

the ugliest friend in a group to make everyone else look better.

Wow, elliot is the duff in that group.

by mobojobo February 2, 2015

Duff

Duff is an acronym meaning Dumb Ugly Fat Friend or Designated Ugly Fat Friend.

Generally a cockblocker and a bitch, have a desperate friend take her down.

Friend 1: Dude I want to hook up with that girl, but her duff is in my way.

Friend 2: It may be Amber but i'll take the duff down.

by Jap Anus Relations July 29, 2009

DUFF

Designated Ugly Fat Friend

Wow, who brought the Duff to the party!?!? Not cool guys...

by DUFF HUNTER August 15, 2009

Duff

a duff is another definition of a noob; a term used when sombody makes a stupid mistake or does something stupid.

Alex: oh my god my ball hairs itch like hell, man.
Morgan: wait, you have hair on your balls.
Alex: wow, your a fucking duff.

by DJCVans June 30, 2006

DUFF

Dangerous Undercover Foxy Female

damn that girl is a duff!@!!

by AshleyHads May 22, 2005