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Medical slang, but can be used anywhere: Means: You're on your own. Used in a hospital on the day of discharge as in the phrase "OOB,OTD, YOYO" : Out of Bed, Out the Door, You're on your own. Can be used by parents of colleged aged kids, or by someone breaking up with someone else. .
I've had it with you, YOYO!
yoyo by DoctorSteve September 12, 2006
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Yoyo-ing 

the act of playing with a yoyo; when you play with a yoyo
Paige was playing with her light-up yoyo, and Steve asked her what she was doing. She replied "Yoyo-ing"
Yoyo-ing by yoyogirl123 March 30, 2010
Related Words
yoyo yoy yoylecake yoyoer yoya Yoy’all yoyeojin Yoyerwack yoyin yoyle

Hoops and YoYo 

two diabolical miscreants who derive extreme pleasure through song and dance. Often causing minor riots from sugar obsessed ten year olds. HYPERACTIVE HELIUM SUCKING CARTOON COMEDY DUO!
Ater three Smirnof Ice you are so Hoops and YoYo!
Hoops and YoYo by Sparrowhauk June 30, 2010
Stands for: Your only young once.
Tom: Hey I bet you won't chug that whole bottle.
Ben: ah idk...
Tom: yoyo bro
Ben: glug* glug* glug*
yoyo by Alex (the man) Rosentreter January 16, 2009
"You're Only Young Once"

YOYO is a motivational phrase that nourishes the pursuit of happiness in young people. Unlike similar abused phrases, such as YOLO, YOYO remains positive and is seldom used by prepubescent girls who seek an excuse to expose their chest or by idiots who need a catchphrase for their Jackass-like stunts.

But there's much more to YOYO...

YOYO is not merely a term. It's a way of thinking. It's a state of mind. The basic principle of YOYO states that the journey, not the destination, is what permeates us with happiness. Thus, the start of the journey, the beginning of our life is of vital importance. The end could be anything. The end could be a slow, painful, lung cancer... or a sudden plane crash. Ergo, the most rational course of action is to give more importance to our youth and not the end.
Adriana tried to butt-rape me with a broom. I said no. She said "Come on! YOYO!"

My friend used to be a meth addict. All he needed to heal was to hear me say, "John, YOYO." - He's been clean for 2 years now.
YOYO by pcordon August 17, 2012
You're On Your Own
"hey babe, i think im pregnant" "oh shit yoyo"
YOYO by ninjamonkeyiscomingforyou February 28, 2013
When you need a poo really badly so you yoyo it in and out of your bumhole
Damn man ive been yoyoing for about an hour, can i use the toilet yet m8
yoyoing by madmuff January 10, 2017