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Uno reverse card 

A powerful weapon of mass destruction used by the Soviets during the battle of Pepe where the radical meme group JOE got asked who joe is witch led to the death of 69 civilians and 420 injuries. The Soviets used the weapon after their motherland was called gay. JOE quickly surrendered but the Soviets had to give up the use after the U.N's ban, due to the increased threat of sanctions and their economy starting to run dry.

Why did I waste my time, was this worth it?
The Uno reverse card killed thousands of blind crippled retarded orphans.
Uno reverse card by T3e May 21, 2020

Uno Block 

IT Blocks Uno Reverse And No U
You: Fuck You
Other Person: Uno Reverse
You: UNO BLOCK
Uno Block by YellowCrewmate June 23, 2021

Uno Más 

Level in Super Mario Maker 2 which features one or several glitches in the game.
I love the ''Uno Más'' series in the DGR YouTube channel
Uno Más by RZKUD March 1, 2022

uno sombrero

Kelli: hes wearing a sombrero.

Kelly: and theres uno.

Kelli and Kelly: UNO SOMBRERO!!

uno ball 

is a term used to describe a man with one ball gone or one ball up and the other hanging down.
Girl, that guy's uno ball was nasty! I left as soon as I saw it!
uno ball by bestognigga August 26, 2011

Uno De Juno 

A holiday in which you goto Chipotle on June 1st, play uno, and eat guacamole & chips.
Person 1: Dude, are you ready for Uno De Juno tomorrow?
Person 2: Yea man!! I made my shirt yesterday and everything!
Uno De Juno by Payback451 June 3, 2006

Uno reverse card 

The best comeback to figuratively and metaphoricaly any argument even if you are already winning. Its impact and feeling contributed in the argument can be summed up in many ways. It is The equivalent to no u, the literal godsend to a victorious argument, the diamond glaz main on plane, the awp in mid, the child predator to church, the yin to the fucking yang, the water bucket to a 50+ block drop, the gaming chair to youtube rewind, the 360 mlg no-scope to any call of duty, the ammo crate to an assault player, the woohoo to a slease sim, the opium to before now china, the smell of napalm in the morning, the thicc belt to your ass, the literal equivalent to fucking god

Your best friends mom

(Ps - if i spelled anything wrong, if i did not use enough parallel structure, or if im just redarted, then its because im a highschooler with 5 children)
Guy 1) *pulls out uno reverse card"

Guy 2 *in universe -10 - 1*) *commits suicide*

Guy 2 *in universe 2-419*) *until dehydration comes full swing*

Guy 2 *in universe 420-1738*) *literally implodes and causes a supernova, the likes of which have never been seen, witnessed, or viewed, ever before*

Guy 3) *Yells "sick burn" until collapse of lungs to the point in which a fucking blackhole is created*

Teacher) *gets sued for doing jack shit* (as usual)

Dad 1 *father of guy 1*) *is getting head from your mom*

Dad 2 *also father of guy 1*) *is gay*