Sometimes known as the ladies' hangover (although men can get them too), its a classier way of saying you're feeling a bit under the weather after a night of drinking, particularly wine. Appropriate for use in mixed company such as at the office or family gatherings.
Julia, you had a lot to drink last night, are you feeling hungover?
No, I'm fine, just a little wine fatigue.
No, I'm fine, just a little wine fatigue.
by Duchess V November 17, 2017

by periaqua May 15, 2020

'Hi Malcolm any chance you could fix my lights?' Do it yourself!!! I'm fed up of your incapacity to get off your fat arse! You're really making me feel the request fatigue now..... fuck off!
by The Don of Witney March 4, 2011

Pocket-Fatigue - The state of never being able to find anything you are carrying in a pocket due to wearing too many items of clothing with pockets. Someone who can not find the things they looking for are said to be suffering from Pocket-Fatigue. The suffering of Pocket-Fatigue generally increases during the winter months.
by Phillip Grimshaw December 20, 2010

A syndrome sweeping the nation after being inundated with too much Sarah Palin. Signs of it's effect are nausea, irritability, annoyance and frustration. Sufferers frequently feel they must resort to leaving the online and television worlds for immediate relief as she can show up in any venue from national news, comedy, politics to entertainment.
Man - I got Palin Fatigue. If I see her face on one more book cover or reality show, I'm gonna hurl. She's everywhere!!! Aaah!!!!
by bklyngrl January 22, 2011

It's the malady that sets in when the user realizes "services" like Foursquare are a complete and utter waste of time.
Hey, I just became Mayor of my workplace! When do I get my pay rise?
Heh - that's only because Mary stopped checking-in on Foursquare. She has total check-in fatigue.
Heh - that's only because Mary stopped checking-in on Foursquare. She has total check-in fatigue.
by Doomnation September 2, 2010

A condition occuring over time to chronically ill patients who have to take a lot of medication, in which the patient stops taking pills because of the stress and monotony of constant pill swallowing.
"I am so tired of taking all my HIV meds. I'm full before I ever get anything to eat."
"Hey man, don't be giving in to pill fatigue now."
"Hey man, don't be giving in to pill fatigue now."
by kitandcaboodle September 9, 2008
