In the duff

When you are horny as fuck

Yo bro are you in the duff right now?

by c0pen September 8, 2020

Duff

The butt

Only some new age duffhole would change the meaning of duff to dumb ugly fat friend or some dumb bloke’s puddin’

by Phil Logenist March 13, 2019

Duff

Verb; meaning to punch or hit.

"Shut up right now, or I'll duff you!"

by AndreaMK December 3, 2006

DUFF

"Everyone has a DUFF"
Designated Ugly Fat Friend

Call up your DUFF...we can get her/him to drive

by xsiennax March 10, 2008

Duff

UK - to be pregnant

She's up the duff

by Sophie96 April 11, 2015

Duff

UK - to be pregnant

She's up the duff

by Sophie96 April 11, 2015

Duff

Designated ugly fat friend

Duff - a less attractive person who has really hot friends and is an easy target to talk too while out at a party/bar too hook them up with the hot friends

by Eloks July 29, 2015