Down syndrome, also known as trisomy 21, is a disease with a connection between mental disability and physical malformation. A downie is a person with this condition.
by TheAlmightyDario April 6, 2020
Get the Downiemug. by Downy Provoker February 18, 2025
Get the Downy Gets Downymug. by Yshshhabavsgsyhwyw August 10, 2022
Get the Downie Ozzie Vrmug. by dykeydownie January 20, 2022
Get the Leona Downiemug. by WeAllHateMason September 8, 2025
Get the Downy Hammermug. When you apply too much Downy Unstoppable and you get unstoppable confidence because you smell good and stuff.
Fat nerd: Wow that old lady who just showed up at our school is sooo cool, it's like she's unstoppable!
Gay nerd: I know she must have Downy Syndrome.
Gay nerd: I know she must have Downy Syndrome.
by Banana Hammie December 19, 2019
Get the Downy Syndromemug. by xxxsmellysalmonxxx69 November 15, 2020
Get the downymug.