DUFF 

Stand for Dumb Ugly Fat Friend

My friend Dora is a DUFF!!!!!!!

DUFF by Rodneyeeee Munch April 22, 2008

DUFF 

Designated Ugly Fat Friend.
typically seen at a bar or night club with any attractive female. They are put on this earth for one reason, to cock block. They usualy give you dirty looks while you talk to there friend then tell you that shes to drunk and makes the girl leave.
YOU WILL ALWAYS SEE A DUFF WITH ANY GOOD LOOKIN CHICK!

"Dude i was so gonna fuck that chick tonight but her fat fuckin duff mad her leave."

"God Damn look at that fuckin DUFF!"

DUFF by finothebamf October 12, 2008

duff 

v. To D/F (direction find)

Break out the Yagi, men, as we must duff the illegal transmitter before it shuts down.

duff by harry flashman August 25, 2003

Duff 

D.u.f.f- Dumb Ugly Fat Fuck, only used with girls but can be used with guys if necessary.

That girl at that lunch table eating jello is a fucking duff

Duff by Kevin Derr May 4, 2007

duff 

Dumb Ugly Fat Friend. Every hot girl has at least one. If, in the case, that a hot girl has other hot girl friends, then they all have at least one mutual duff. Hot girls chill with them to usually make themselves seem better.

Yo dawg, we gotta get this DUFF away asap.

duff by the_realest_MI March 4, 2011

Duff 

Designated Unpopular Fat Friend. A fat person,usually a female who is obsessed with a country boy,his friends,his momma,sister,truck and dog.

Girl: Where did all my ice cream go?
Boy: The duff must have ate it.

Duff by brotherman94 February 8, 2012

Duff 

The cannabis material that is left after vaporization (which it is still good for cooking).

I made awesome brownies with the duff from last weeks party!

Duff by CaraBeantown January 5, 2014